FREQUÊNCIAS ALÉLICAS EM IFI16 E AIM2 DE UMA POPULAÇÃO BRASILEIRA MISCIGENADA E NAS POPULAÇÕES AFRICANA E EUROPEIA

Authors

  • Márcia Otto Barrientos Barrientos Escola de Saúde, Centro Universitário Adventista do Nordeste - UNIAENE Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil; https://orcid.org/0000-0001-5603-2448
  • Álvaro Augusto Cruz Programa de Controle da Asma na Bahia (PROAR), Universidade Federal da Bahia, Salvador, Bahia, Brasil. https://orcid.org/0000-0002-7403-3871
  • Jônatas Barbosa Fabrício da Silva Escola de Saúde, Centro Universitário Adventista do Nordeste - UNIAENE https://orcid.org/0009-0002-4762-1587
  • Daniele Vieira Reis Escola de Saúde, Centro Universitário Adventista do Nordeste - UNIAENE https://orcid.org/0009-0006-7022-1185
  • Helena Mariana Pitangueira Teixeira Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil https://orcid.org/0000-0003-2811-9401
  • Raimon Rios da Silva Escola de Saúde, Centro Universitário Adventista do Nordeste – UNIAENE https://orcid.org/0000-0002-3422-0453
  • Adelmir Souza-Machado Programa de Controle da Asma na Bahia (PROAR), Universidade Federal da Bahia, Salvador, Bahia, Brasil. https://orcid.org/0000-0002-1475-2663
  • Ryan dos Santos Costa Departamento de Bioregulação, Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil https://orcid.org/0000-0003-3075-0729
  • Camila Alexandrina Viana de Figueiredo Departamento de Bioregulação, Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil https://orcid.org/0000-0003-1356-6188
  • Tatiane de Oliveira Teixeira Muniz Carletto Departamento de Bioregulação, Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil https://orcid.org/0000-0001-7998-2569

DOI:

https://doi.org/10.25194/rebrasf.v11i2.1656

Keywords:

Populações de Ascendência Africana, Grupo de Ancestralidade no Continente Europeu, Alelos, IFI16, AIM2

Abstract

Introduction: The population of Salvador/Bahia is among the first formed in colonial Brazil and was influenced by different peoples. This study analyzed the allele frequency of variants in the genes Interferon Gamma Inducible Protein 16 (IFI16) and Absent in Melanoma 2 (AIM2) in a population from Salvador/Bahia/Brazil with reference populations, verified their regulatory potential, and described associated diseases in different populations. Method: Cross-sectional, structured cohort study on asthma and periodontitis (n=1094). Information was extracted from the Illumina Multi-Ethinic AMR/AFR-8 chip. Comparison of the frequency of the polymorphic allele of the genetic variants of IFI16 and AIM2 was carried out between individuals from Salvador and African and European populations. Results: The allele frequencies of genetic variants in IFI16 in the studied population were more similar to those of Europeans. Of the 50 IFI16 variants, 08 had a polymorphic allele frequency greater than 40% and 07 between 20% and 39% and of the 26 in AIM2, 01 had a frequency greater than 40% and 04 between 20 and 39%. The most significant regulatory potential verified in IFI16 occurred in 5 variants with classification 3a. In AIM2, 2 presented classification 2b and 3a. Conclusion: Comparison analysis of the frequency of alleles of genetic variants in IFI16 suggests a greater genetic influence of European than African ancestral peoples. In AIM2 the results did not agree. Analyzes of the association of polymorphic alleles with the pathologies described in the literature and validation of the results found in this study in other populations of the same studied region are suggested.

Author Biography

Márcia Otto Barrientos Barrientos, Escola de Saúde, Centro Universitário Adventista do Nordeste - UNIAENE Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia-UFBA, Salvador, Bahia, Brasil;

Saúde - bioquímica, farmacologia, psicofarmacologia, química, farmácia.

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Published

2023-10-27

How to Cite

Barrientos, M. O. B., Cruz , Álvaro A., Barbosa Fabrício da Silva, J., Vieira Reis, D., Pitangueira Teixeira , H. M., Rios da Silva, R., Souza-Machado, A., dos Santos Costa , R., Viana de Figueiredo , C. A., & de Oliveira Teixeira Muniz Carletto, T. (2023). FREQUÊNCIAS ALÉLICAS EM IFI16 E AIM2 DE UMA POPULAÇÃO BRASILEIRA MISCIGENADA E NAS POPULAÇÕES AFRICANA E EUROPEIA. Revista Brasileira De Saúde Funcional, 11(2). https://doi.org/10.25194/rebrasf.v11i2.1656

Issue

Vol. 11 No. 2 (2023): REBRASF - Edição Suplementar COSUDI 2023

Section

Artigos