PHOTODYNAMICS THERAPY AS AN ADJUVANT IN DISINFECTING CHANNEL SYSTEM: A LITERATURE REVIEW
DOI:
https://doi.org/10.25194/rebrasf.v10i2.1502Abstract
Introduction:Technological advances in the field of Dentistry aim to minimize invasive procedures, in order to improve the quality of care and efficiency in treatments. Photodynamic therapy (PDT) plays an important role in the disinfection of root canals, without adverse effects or damage to the dental elements and adjacent soft tissues. Objective: To discuss PDT and its use in the disinfection of adjuvant root canals to conventional chemical-mechanical preparation. Materials and Methods: This is a narrative literature review carried out through bibliographic collection in SciELO, PubMed, Google Academic and Lilacs data bases, from February to August 2021. The inclusion criteria established were publications on the subject, from 2011 to 2021 and written in English and Portuguese. The crossing of DeCS/MeSH descriptors used the terms “endodontics”, “endodontia”, “fotoquimioterapia”, “photochemotherapy”, “limpeza de canais radiculares”, and “root canal cleaning”, associated with the Boolean operator“AND”.After the exclusion steps, a total of 47 articles were selected for this study. Results: Some bibliographic studies showed that PDT is effective as an adjuvant to endodontic treatment and capable of enhancing the root canal disinfection process, significantly reducing the amount of microorganisms present in the canals. Conclusion: Thus, it is observed that PDT can be used as an adjuvant to conventional endodontic treatment without harming patients. However, more randomized clinical studies are needed with the aim of establishing clinical protocols for the use of PDT as an adjuvant to endodontic treatment, aiming at reducing the failure rates of endodontic therapy and collaborating with the preservation of the dental unit.
References
Luckmann G, Dorneles LC, Grando CP. Etiologia dos insucessos dos tratamentos endodônticos. Vivências. 2013;9(16):133-9. Disponível em: http://www2.reitoria.uri.br/~vivencias/Numero_016/artigos/pdf/Artigo_14.pdf. Acesso em: 5 fev 2021.
Canto D, Victorino FR. Avaliação do índice de sucesso de tratamentos endodônticos realizados por alunos de graduação. Dental Press Endod. 2012;2(2):25-9. Disponível em: http://www.cesumar.br/prppge/pesquisa/epcc2013/oit_mostra/Dhebora_do_Canto.pdf. Acesso em: 5 fev 2021.
De Martin G, Azeredo RA. Análise de preparo de canais radiculares utilizando-se a diafanização. Rev Odontol UNESP. 2014;43(2):111-8. Disponível em: https://www.scielo.br/j/rounesp/a/BHkCbV8Z6phqw6JDtCkLVDm/?format=pdf&lang=pt. Acesso em: 7 fev 2021.
Eduardo CP, Bello-Silva MS, Ramalho KM, Lee EMR, Aranha ACC. A terapia fotodinâmica como benefício complementar na clínica odontológica. Rev Assoc Paul Cir Dent. 2015;69(3):226-35. Disponível em: http://revodonto.bvsalud.org/pdf/apcd/v69n3/a04v69n3.pdf . Acesso em: 5 fev 2021.
Carrera ET, Dias HB, Corbi SCT, Marcantonio RAC, Bernardi ACA, Bagnato VS et al. The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review. Laser Phys. 2016;26(12):1-5. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29151775/. Acesso em: 5 fev 2021.
Siqueira JF, Rôças IN. Optimising single-visit disinfection with supplementary approaches: A quest for predictability. Aust Endod J. 2011;37:92-8. Disponível em: http://drzoufan.com/wp-content/uploads/2015/05/Single-Visit-vs-Dual-Visit.pdf. Acesso em: 16 fev 2021.
Garcez AS, Nuñez SC, Hamblim MR, Suzuki H, Ribeiro MS. Photodynamic Therapy Associated with Conventional Endodontic Treatment in Patients with Antibiotic-resistant Microflora: A Preliminary Report. J Endod. 2010;36(9):1463-6. Disponível em: https://www.researchgate.net/profile/Aguinaldo-Garcez/publication/45799179_Photodynamic_Therapy_Associated_with_Conventional_Endodontic_Treatment_in_Patients_with_Antibiotic-resistant_Microflora_A_Preliminary_Report/links/5c5c0eba299bf1d14cb2210d/Photodynamic-Therapy-Associated-with-Conventional-Endodontic-Treatment-in-Patients-with-Antibiotic-resistant-Microflora-A-Preliminary-Report.pdf. Acesso em: 11 fev 2021.
Schaeffer B, D'Aviz FS, Ghiggi PC, Klassmann LM. Terapia fotodinâmica na endodontia: revisão de literatura. Journ of Oral Investig. 2019; 8(1):86-99. Disponível em: https://seer.imed.edu.br/index.php/JOI/article/view/2779/html. Acesso em: 5 fev 2021.
Oliveira BP, Lins CC, Diniz FA, Melo LL, Castro CM. In Vitro antimicrobial photoinactivation with methylene blue in different microorganisms. Braz. J. Oral Sci. 2014;13(1):53-7. Disponível em: https://www.scielo.br/j/bjos/a/xrGrthGVWGYtQhgKcVJCBBd/?lang=en. Acesso em: 7 fev 2021.
Rocha TA, Cerqueira JD, Carvalho ÉS. Infecções endodônticas persistentes: causas, diagnóstico e tratamento. Rev. Ciênc. Méd. Biol.2018;17(1):78-83. Disponível em: https://periodicos.ufba.br/index.php/cmbio/article/view/23276. Acesso em: 7 fev 2021.
Alfenas CF, Santos MF, Takehara GN, Paula MV. Terapia fotodinâmica na redução de micro-organismos no sistema de canais radiculares. Rev. bras. odontol. 2011;68(1):68-71. Disponível em: https://revista.aborj.org.br/index.php/rbo/article/view/255. Acesso em: 5 fev 2021.
Campos FL, Guimarães LC, Almeida GC, Viana AD. Causas de insucessos no tratamento endodôntico – análise dos casos de retratamento atendidos no projeto de extensão da Faculdade de Odontologia da UFMG. Arq. Odontol. 2017;53:1-8. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-906792. Acesso em: 11 de fev 2021
Celso NC, Aloma SO, Michelle CB. Tecnologia a serviço da endodontia: Avanços no diagnóstico e tratamento de canais radiculares. Rev. Hu. 2018;44:55-61. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/13928. Acesso em: 11 de fev 2021.
Nery MJ, Cintra LTA, Gomes-Filho JE, Dezan-Junior E, Otoboni-Filho JA, Sivieri-Araujo G et al. Estudo longitudinal do sucesso clínico-radiográfico de dentes tratados com medicação intracanal de hidróxido de cálcio. Rev de Odont da UNESP, 2012;41:396-401. Disponível em: https://www.scielo.br/j/rounesp/a/hVP9BgGs454b7VQ4969WRgS/?lang=pt. Acesso em: 15 fev 2021.
Pretel H, Bezzon F, Faleiros FBC, Dametto FR, Vaz LG. Comparação entre soluções irrigadoras na endodontia: clorexidina x hipoclorito de sodio. Revista Gaúcha de Odontologia. 2011;59:127-32. Disponível em: http://revodonto.bvsalud.org/scielo.php?script=sci_arttext&pid=S1981-86372011000500018. Acesso em: 10 fev 2021.
Arneiro RAS, Nakano RD, Antunes LAA, Ferreira GB, Fontes KBFC, Antunes LS. Efficacy of antimicrobial photodynamic therapy for root canals infected with Enterococcus faecalis. J Oral Sci. 2014;56(4):277-85. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25500925/. Acesso em: 15 fev 2021.
Pagonis TC, Chen J, Fontana CR, Devalapally H, Ruggiero K, Song X et al. Nanoparticle-based endodontic antimicrobial photodynamic therapy. J Endod. 2010;36(2):322. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20113801/. Acesso em: 5 fev 2021.
Samiei M, Shahi S, Abdollahi AA, Eskandarinezhad M, Negahdari R, Pakseresht Z. The Antibacterial Efficacy of Photo-Activated Disinfection, Chlorhexidine and Sodium Hypochlorite in Infected Root Canals: An in Vitro Study. Iran Endod J. 2016;11(3):179-83. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947840/. Acesso em: 10 fev 2021.
Davis JM, Maki J, Bahcall JK. An In Vitro Comparison of the Antimicrobial Effects of Various Endodontic Medicaments on Enterococcus faecalis. J Endod 2007;33(5):567-9. Disponível em: https://pubmed.ncbi.nlm.nih.gov/17437873/. Acesso: 7 fev 2021.
Lynne RE, Liewehr FR, West LA, Patton WR, Buxton TB, Mcpherson JC. In Vitro Antimicrobial Activity of Various Medication Preparations on E. faecalis in Root Canal Dentin. J Endod. 2003;22(5): 356-65. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12669878/. Acesso em: 15 fev 2021.
Siqueira Jr JF, Guimarães-Pinto T, Rôças IN. Effects of chemomechanical preparation with 2.5% sodium hypochlorite and intracanal medication with calcium hydroxide on cultivable bacteria in infected root canals..J Endod 2007;33(7):800–5. Disponível em: https://pubmed.ncbi.nlm.nih.gov/17804315/. Acesso em: 5 fev 2021.
Almyroudi A, Mackenzie D, McHugh S, Saunders WP. The effectiveness of various disinfectants used as endodontic intracanal medications: an in vitro study. J Endod. 2002; 28(3):163-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12017172/. Acesso em: 5 fev 2021.
De Oliveira RF, Silva LPDL, Silva FVD, Andrade KDS, Moreira Romão TC, Dos Santos MGC et al. Terapia fotodinâmica associada a laser no tratamento endodôntico. Arch Health Invest [Internet]. 2021;10(2):236-40. Disponível em: https://www.archhealthinvestigation.com.br/ArcHI/article/view/5051. Acesso em: 5 fev 2021.
Garcez AS, Ribeiro MS, Tegos GP, Núñez SC, Jorge AOC, Hamblin MR. Antimicrobial Photodynamic Therapy Combined With Conventional Endodontic Treatment to Eliminate Root Canal Biofilm Infection. Lasers Surg Med. 2007;39(1):59-66. Disponível em: https://pubmed.ncbi.nlm.nih.gov/17066481/. Acesso em: 7 fev 2021.
Song M,Kim HC, Lee W, Kim E. Analysis of the Cause of Failure in Nonsurgical Endodontic Treatment by Microscopic Inspection during Endodontic Microsurgery. Journal of Endodontics. 2011;37(11):1516-9. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22000454/. Acesso em: 5 fev 2021.
Carneiro VSM, Catão MHCV. Aplicações da terapia fotodinâmica na odontologia. Ver FacOdont de Lins. 2012;22(1): 25-32. Disponível em: https://www.metodista.br/revistas/revistas-unimep/index.php/Fol/article/view/248. Acesso em: 5 fev 2021.
Issa MCA, Manela-Azulay M. Terapia fotodinâmica: revisão da literatura e documentação iconográfica. Anais Bras de Dermat, 2010;85(4):501-11. Disponível em: https://www.scielo.br/j/abd/a/CcpZfpFQJYr4MdTygs8FpkF/abstract/?lang=pt. Acesso em: 7 fev 2021.
Oliveira FCS, Cabral GM, Eler JFC, Pimentel SJ, Peixoto VR, Paranhos WJ et al. Azul de metileno para fins terapêuticos. Braz. J. Surg. Clin. Res. 2019; 27(2): 66-70. Disponível em: https://www.mastereditora.com.br/periodico/20190704_104220.pdf. Acesso em: 20 fev 2021.
ITO T. Toluidine Blue: The mode of photodynamic action in yeast cells. Photochem. Photobiol. 1977;25(2):47-53. Disponível em: https://pubmed.ncbi.nlm.nih.gov/322164/. Acesso: 5 fev 2021.
Wanderley RB, dos Santos SM, da Silva JGR, Leite JVC, Suassuna FCM, da Silva BJ. Terapia fotodinâmica no tratamento endodôntico: Uma revisão integrativa. Research, Society and Development. 2021;10(9): e48610918142-e48610918142. Disponível em: file:///C:/Users/User/Downloads/18142-Article-228461-1-10-20210731.pdf. Acesso em: 20 fev 2021.
Simplicio FI, Maionchi F, Hioka N. Terapia fotodinâmica: aspectos farmacológicos, aplicações e avanços recentes no desenvolvimento de medicamentos. Químic Nova. 2002;25(5):801-7. Disponível em: https://www.scielo.br/j/qn/a/yM7QMHW8Mr7LzsHBbcNZ49k/?lang=pt. Acesso em: 11 fev 2021.
Eduardo CDP, Bello-Silva MS, Ramalho KM, Lee EMR, Aranha ACC. A terapia fotodinâmica como benefício complementar na clínica odontológica. Revista da Associ Paulist de Cirurg Dentist. 2015;69(3):226-35. Disponível em: http://revodonto.bvsalud.org/scielo.php?script=sci_arttext&pid=S0004-52762015000200004. Acesso em: 14 fev 2021.
Moreira ALG, Monteiro AMD, Rios MA. Terapia fotodinâmica para a redução microbiana no tratamento das doenças periodontais: revisão de literatura. Rev Perio. 2011;21(1):65-72. Disponível em: http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS&lang=p&nextAction=lnk&exprSearch=642581&indexSearch=ID. Acesso em 14 fev 2021.
De Oliveira BP, Aguiar CM, Câmara AC, de Albuquerque MM, Correia AC, Soares MF. The efficacy of photodynamic therapy and sodium hypochlorite in root canal disinfection by a single-file instrumentation technique. Photodiagnosis Photodyn Ther. 2015;12(3):436-43. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26007242/. Acesso em: 16 fev 2021.
Lima SP, Sousa ET, Melo MO, Silva MS. Photodynamic therapy as an aiding in the endodontic treatment: case report. RGO, Rev Gaúch Odontol. 2019;67(30):1-5. Disponível em: https://www.scielo.br/j/rgo/a/9vhxTKjh5MRs78MBRNNsfBG/?lang=en. Acesso em: 24 fev 2021.
Garcez AS; Roque JA; Murata WH; Hamblin MR. Uma nova estratégia para PDT antimicrobiana em Endodontia. Rev Assoc Paul Cir Dent. 2016;70(2):126-30. Disponível em: http://revodonto.bvsalud.org/pdf/apcd/v70n2/a05v70n2.pdf. Acesso em 24 fev 2021.
Saatchi M, Shokraneh A, Navaei H, Maracy MR, Shojaei H. Antibacterial effect of calcium hydroxide combined with chlorhexidine on Enterococcus faecalis: a systematic review and meta-analysis. J Appl Oral Sci. 2014;22(5):356-65. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25466470/. Acesso: 24 fev 2021.
Susila AV, Sugumar R, Chandana CS, Subbarao CV. Combined effects of photodynamic therapy and irrigants in disinfection of root canals. J Biophotonics. 2016;9(6):603-9. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26235897/. Acesso: 8 fev 2021.
Ng R, Singh F, Papamanou DA, Song X, Patel C, Holewa C, Patel N, Klepac-Ceraj V, Fontana CR, Kent R, Pagonis TC, Stashenko PP, Soukos NS. Endodontic photodynamic therapy ex vivo. J Endod. 2011;37(2):217-22. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21238805/. Acesso em: 24 fev 2021.
Viana BAS, Endo MS, Pavan NNO. Uso da terapia fotodinâmica na redução de microrganismos das infecções endodônticas. Arch Health Invest, 2021;10(3):474-9. Disponível em: https://www.archhealthinvestigation.com.br/ArcHI/article/view/4722. Acesso em: 26 fev 2021.
Mesquita KS, Queiroz AM, Nelson-Filho P, Borsatto MC. Terapia fotodinâmica: Tratamento promissor na odontologia? Rev de literatura/Bibliography Review, 2013;23(2):1-8. Disponível em: https://www.metodista.br/revistas/revistas-unimep/index.php/Fol/article/view/1849. Acesso em: 10 fev 2021.
Asnaashari M, Godiny M, Azari-Marhabi S, Tabatabaei FS, Barati M. Comparison of theAntibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy in Reducing the Microbial Flora of Root Canal in EndodonticRetreatment in Patients with Periradicular Lesions. J Lasers Med Sci. 2016;7(2):99-104. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27330705/. Acesso em: 7 fev 2021.
Soares JA, Santos Soares SMC, Santos CCA, de Carvalho MAR, Brito-Júnior M, de Sousa GR et al. Monitoring the effectiveness of photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms. Photodiagnosis Photodyn Ther. 2016;13:123-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26796030/. Acesso em: 26 fev 2021.
Jurič IB, Plečko V, Pandurić DG, Anić I. The antimicrobial effectiveness of photodynamic therapy used as an addition to the conventional endodontic re-treatment: a clinical study. Photodiagnosis Photodyn Ther. 2014;11(4):549-55. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25461966/. Acesso em: 26 fev 2021.
Rios A, He J, Glickman GN, Spears R, Schneiderman ED, Honeyman AL. Evaluation of photodynamic therapy using a light-emitting diode lamp against Enterococcus faecalis in extracted human teeth. J Endod. 2011;37(6):856-9. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21787505/. Acesso em: 10 fev 2021.
Souza LC, Brito PR, de Oliveira JC, Alves FR, Moreira EJ, Sampaio-Filho HR, Rôças IN, Siqueira JF Jr. Photodynamic therapy with two different photosensitizers as a supplement to instrumentation/irrigation procedures in promoting intracanal reduction of Enterococcus faecalis. J Endod. 2010;36(2):292-6. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20113793/. Acesso em: 5 fev 2021.
Xhevdet A, Stubljar D, Kriznar I, Jukic T, Skvarc M, Veranic P, Ihan A. The disinfecting efficacy of root canals with laser photodynamic therapy. J Lasers Med Sci. 2014;5(1):19-26. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25606335/. Acesso em: 7 fev 2021.