ASSOCIATION BETWEEN NON-MOTOR SYMPTOMS AND FALLS IN INDIVIDUALS WITH PARKINSON’S DISEASE: SYSTEMATIC REVIEW
DOI:
https://doi.org/10.25194/rebrasf.v11i1.1468Keywords:
Parkinson Disease, anxiety, sleep initiation, accidental falls, systematic review.Abstract
ABSTRACT
Introduction: Parkinson's disease (PD) is a neurodegenerative disease that affects the basal ganglia, specifically dopamine, closely related to the mechanisms of reward and behavior reinforcement. This explains the number of individuals with PD with non-motor symptoms, such as depression, anxiety, impulsivity, pain, insomnia, mood changes. It seems that there is a strong participation of non-motor symptoms in the fall. However, few studies show an association or not with falls in these individuals. Objective: To review in the literature the association between non-motor signs and symptoms and falls in individuals with PD. Methodology: This is a literature review. Search carried out in the Pubmed, Scielo, Lilacs and Medline databases between October and November 2021. Case-control or cohort studies that had the theme: non-motor signs and symptoms of individuals with PD associated with falls were included, according to the NMS SCALE. Those who did not appear on the scale were excluded, as well as duplicates in the databases. Results: Search resulted in 33 studies in the first phase, but 4 of them were not found for full reading. After reading the 29 studies, 17 were excluded by the outcome and only 12 were selected. Total 1467 patients studied. Discussion: Non-motor symptoms in PD have become increasingly limiting of functionality and motricity in these individuals and strong influencers of falls, a major cause of death. Conclusion: There is a high significance of certain non-motor symptoms directly related to falls and the functional status of individuals with Parkinson's.
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